A.Ju. Gromova, A.5. Simbirtsev State Research Institute
of Highly Pure Biopreparations, St. Petersburg
Functional polymorphisms of IL-1 family genes
influences the level of cytokines production and defence reactions development,
because just these cytokines have the biggest impact on the regulation of
inflammation and consequently on specific immune response. In this review we
summarize the data on the frequencies of various IL-1 family alleles in
different human populations and discuss the linkage between certain alleles and
the development of inflammation, predisposition to human pathology, and
different ways of immunotherapy. According to obtained data, cytokine
genotyping could become one of the potent criteria for individual correction of
immune system and for specific therapy. (Cytokines and Inflammation. 2005. Vol.
4, № 2. P. 3-12.)
Key words: IL-1 family cytokines, gene
polymorphisms, inflammation, predisposition to human pathology, therapy.