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8.2 Phenothiazines
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8.2 Phenothiazines

The electrophysiological properties of phenothiazines are comparable to those of the Class Ia antiarrhythmics (as quinidine). Numerous ECG aberrations may be induced by these agents, including changes in the morphology of the T wave, prolongation of the QT interval, and accentuation of the U wave. Supraventricular and ventricular tachycardias have been reported in patients receiving high doses of phenothiazines. Even with standard clinical dosages (100-400 mg/day), thioridazine causes minimal prolongation of the QT interval, reduction of T wave amplitude, and prominent U waves in nearly 50 percent of patients.



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