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Morphometric investigation of immunoregulatory and effector cells in aorta and paraaorticlymph nodes in human atherogenesisP.V. PigarevskyInstitute of Experimental Medicine, St. Petersburg
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Morphometric investigation of immunoregulatory and effector cells in aorta and paraaorticlymph nodes in human atherogenesisP.V. PigarevskyInstitute of Experimental Medicine, St. Petersburg

The aim of the study was to evaluate the role of immunoregulatory and effector lymphoid cells in hu"man atherogenesis.  Immunomorphological and morphometric study was carried out using monoclonalantibodies against T and B lymphocytes’ subpopulations. The increase of CD4+ lymphocytes’ and HLADR+ mononuclears’  count  in  intima and adventitia of aorta,  T and B"dependent areas of paraaorticlymph nodes was revealed in humans aged 31–60. These changes were accompanied by the increase ofIgG producing B lymphocytes’ count in the same regions of aorta and B"dependent areas of paraaorticlymph nodes. At the same time, there was no increase of CD8+ lymphocytes’ count. No significant im"munomorphological  changes were observed  in  spleen  peripheral  lymphoid organ being away  fromaorta. Probable mechanisms and  specific  features of  immune  inflammation  in human atherogenesisare discussed.Key words: atherogenesis, paraaortic lymphnodes, T and B lymphocytes.



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