çàãðóçêà...
 
Interleukin 4, interferon gamma and immunoglobulin E in expired air condensate inbronchial asthma and allergic rhinitis ch IL-dren the prognostic valueT.N. Sourovenko, Y.S. Sheludko, O.V. Ovchinnikova, E.V. Markelova, B.I. Geltser Vladivostok State Medical University,  Laboratory of Immunology, Central Hospital of Pacific Ocean Fleet, Far East Branch of Institute of Clinical Immunology, Siberian Branch of Russian Academy of MedicalSciences, Vladivistok
Ïîâåðíóòèñü äî çì³ñòó

Interleukin 4, interferon gamma and immunoglobulin E in expired air condensate inbronchial asthma and allergic rhinitis ch IL-dren the prognostic valueT.N. Sourovenko, Y.S. Sheludko, O.V. Ovchinnikova, E.V. Markelova, B.I. Geltser Vladivostok State Medical University,  Laboratory of Immunology, Central Hospital of Pacific Ocean Fleet, Far East Branch of Institute of Clinical Immunology, Siberian Branch of Russian Academy of MedicalSciences, Vladivistok

The aim of the study was to investigate IL-4, IFN gamma and IgE levels in expired air condensat (EAC)of bronchial asthma  (BA) and allergic  rhinitis  (AR)  chIL-dren with  sensitization  to house dust mites(HDM) allergens. 34 BA and 16 AR patients aged from 4 to 18 years old were  included  in trial. ELISAmethod with «R&D Diagnostics Inc.» kits was used to investigate IL-$4 and IFN gamma levels; IgE levelwas evaluated by means of «Vector$Best»  test systems (Russia).  The  increase of  local  IL-4  secretionwas revealed in BA and AR patients (7,68 ± 3,14 and 5,36 ± 1,75 pg/ml respectively), whIL-e the levelof  IFN gamma was  relatively  low  (3,92 ± 1,16 pg/ml) with high  IL-$4/IFN gamma  ratio, especially  incases of BA exacerbation (10–30). IgE level in EAC samples of BA and AR patients varied from 5 to 330IU/ml, in these of healthy controls the level was lower than 20 IU/ml in all the cases. No correlationswere found between IgE level and asthma severety and phase. However, the trend towards the correla$tion between HDM  levels and  IgE  (r = 0,38) was  revealed. HDM exposure was higher  in patients withhigh IL-$4 and IgE levels in EAC. Thus, the increase of IL-$4 and IgE levels in EAC as well as higher IL-$4/IFN gamma ratio are considered to be the markers of allergic inflammation in airways. The use of thesemarkers for selection of patients for local immunotherapy can be discussed.Key words: expired air condensate, IL-04, IFN gamma, IgE.



çàãðóçêà...