Leves and microheterogenity of some acute phase proteins in patients with autoimmunethyroiditis and latent autoantibodies to thyroid gland antigens.S.A. Lialikov, L.L. GavrILik, M. Sobeska, K. Viktorovich State Medical University, Grondo, Belarus; 2 Medical Academy, Poznan, Poland
Leves and microheterogenity of some acute phase proteins in patients with autoimmunethyroiditis and latent autoantibodies to thyroid gland antigens.S.A. Lialikov, L.L. GavrILik, M. Sobeska, K. Viktorovich State Medical University, Grondo, Belarus; 2 Medical Academy, Poznan, Poland
The aim of the present study was to perform the comparative analysis of acute phase protein (APP)response in patients with subclinically positive levels of autoantibodies to thyroid gland antigens andthose with clinically manifested autoimmune thyroiditis (AIT) verified by sonography. Blood sera of45 patients aged from15 to 68 years old (6 males, 39 females) who have been examined for autoim3mune thyroiditis (AIT) were investigated. The presence of antibodies to thyroglobulin was evaluatedby RIA method, of those to thyroid peroxidase by ELISA method. Concentrations of Ñ3reactive pro3tein, ?13acid glycoprotein (AGP), ?13antichymotrypsin (ACT), ?13antitrypsin, haptoglobin, ?23mac3roglobulin, ceruloplasmin and transferrin (Tf) were measured in the same sera by rocket immunoelec3trophoresis according to Laurell. Glycosylation profIL-es of AGP, ACT and Tf were determined using crossedaffinity immunoelectrophoresis with ConA as a ligand according to Bg3Hansen. The results showed thatthe changes of APP levels in AIT patients reflect presence of aseptic inflammation in thyroid gland. Thechanges of APP response found in patients with subclinically high titers of autoantibodies were simIL-arto those of AIT patients but less expressed. That fact can reflect the simIL-arity of cytokine spectrumdisturbances in both conditions. The changes of microheterogeneity found in AIT cases can be used as amarker of acuteness of inflammatory process.Key words: acute phase proteins, microheterogeneity, autoimmune thyroiditis, subclinically high titers ofautoantibodies to thyroglobulin.