V.I. Konenkov,I.G. Rakova, V.V. Avdoshina, E.L.
Gelfgat Institute of Clinical Immunology, Siberian Branch of RAMS, Novosibirsk
The purpose of the study was a complex
estimation of cytokine spontaneous production in supernatants of cultured
mononuclear cells of healthy Caucasians. Matching the level of cytokines in
various groups was carried out and it was detected that INFy production by Th1
cells predominated IL-2 production by the same cells. The analysis of Th2 group
cytokines detected predominance of IL-6 production among the other cytokines.
It was also revealed in healthy people that IL-4 production exceeds the
production of IL-13, another co-stimulator of pre-activated B cells
proliferation. The comparison of concentrations of the growth factors showed
that the intensity of G-CSF production was much higher, than the production of
GM-CSF. The concentration of IL-8 was significantly higher than the
concentration of another chemokines. The complex spontaneous cytokine
production estimation revealed their significant dependency upon the age and
gender. (Cytokines and Inflammation. 2005. Vol. 4, № 2. P. 33-37.)