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Origin of Agglutinins in the Plasma
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Origin of Agglutinins in the Plasma

The agglutinins are gamma globulins, as are almost all antibodies, and they are produced by the same bone marrow and lymph gland cells that produce antibodies to any other antigens. Most of them are IgM and IgG immunoglobulin molecules.

But why are these agglutinins produced in people who do not have the respective agglutinogens in their red blood cells? The answer to this is that small amounts of type A and B antigens enter the body through food, through bacteria, and other ways, and these substances initiate the development of the anti-A and anti-B agglutinins. For instance, infusion of group A antigen into a recipient having a non-A blood type causes a typical immune response with formation of greater quantities of anti-A agglutinins than ever.Also, the neonate has few, if any, agglutinins, showing that agglutinin formation occurs almost entirely after birth.



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